Revelation 16:1 And I heard a great voice out of the temple saying to the seven angels, Go your ways, and pour out the vials of the wrath of God upon the earth.
2 And the first went, and poured out his vial upon the earth; and there fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image.
Now God begins to have the angels pour out the last of the judgments. The angels may be reluctant to bring this destruction but because the are obedient to God they do not hesitate. The first vial brought noisome and grievous sores upon all those that worshiped the Antichrist or had his mark. This means that the saints or followers of Christ will not be harmed by this plague, they will be protected as God has promised. Now you may say I can stay true to God if I miss the rapture but you do not need to take that chance because it will way harder than you can imagine simply because the the Holy Spirit will not have the same roll in the tribulation that He has now of convicting us when we do wrong. Also these plagues do not begin til the last half of the tribulation, right after you have been commanded to take the mark of the beast or die.